Biocompatibility of poly (DL-lactic acid/glycine) copolymers
نویسندگان
چکیده
منابع مشابه
In vitro degradation of glycine/DL-lactic acid copolymers.
The in vitro degradation of glycine-DL-lactic acid copolymers was studied as a function of the composition. These polydepsipeptides were prepared by ring-opening copolymerization of 6-methyl-2,5-morpholinedione and DL-lactide. The degradation of discs of the copolymers was performed in a phosphate buffer at pH 7.4 and 37 degrees C. The decrease in molecular weight and weight was determined unti...
متن کاملBiodegradation and Biocompatibility of Poly L-lactic Acid Implantable Mesh
PURPOSE The purpose of this study was to evaluate the biodegradation and biocompatibility of poly L-lactic acid (PLLA) implantable mesh under in vitro and in vivo conditions. METHODS PLLA mesh was examined for changes in weight and tensile strength. The histology of the tissue around the PLLA implant was also evaluated. RESULTS The weight and tensile strength of the PLLA prosthesis was stab...
متن کاملSize-Controlled Nanomicelles of Poly(lactic acid)–Poly(ethylene glycol) Copolymers with a Multiblock Configuration
The ability to control the micelle size of poly(lactic acid) and poly(ethylene glycol) (PLA–PEG) block copolymers is important for controlling their circulation in blood cell recognition, drug release and therapeutic effects. We successfully controlled the micelle size by changing the block number of copolymers (multiblock index). PLA–PEG multiblock copolymers with multiblock indexes ranging fr...
متن کاملIn vivo and in vitro degradation of glycine/DL-lactic acid copolymers.
A series of copolymers of glycine and DL-lactic acid with various compositions was synthesized and their in vivo and in vitro degradation behavior was studied. For the in vivo examination, discs of the copolymer films were subcutaneously implanted in rats. The in vitro studies were carried out in phosphate buffer at pH = 7.4 and 37 degrees C. The decrease in molecular weight, the loss of weight...
متن کاملPreparation of Cylinder-Shaped Porous Sponges of Poly(L-lactic acid), Poly(DL-lactic-co-glycolic acid), and Poly(ε-caprolactone)
Design of mechanical skeletons of biodegradable synthetic polymers such as poly(L-lactic acid) (PLLA), poly(DL-lactic-co-glycolic acid) (PLGA), and poly(ε-caprolactone) (PCL) is important in the construction of the hybrid scaffolds of biodegradable synthetic polymers and naturally derived polymers such as collagen. In this study, cylinder-shaped PLLA, PLGA, and PCL sponges were prepared by the ...
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ژورنال
عنوان ژورنال: Clinical Materials
سال: 1991
ISSN: 0267-6605
DOI: 10.1016/0267-6605(91)90067-p